Newest publications
Identification of novel genes including NAV2 associated with isolated tall stature
(2023) Weiss, Birgit; Ott, Tim; Vick, Philipp; Lui, Julian C.; Roeth, Ralph; Vogel, Sebastian; Waldmüller, Stephan; Hoffmann, Sandra; Baron, Jeffrey; Wit, Jan M.; Rappold, Gudrun A.
Very tall people attract much attention and represent a clinically and genetically heterogenous group of individuals. Identifying the genetic etiology can provide important insights into the molecular mechanisms regulating linear growth. We studied a three-generation pedigree with five isolated (non-syndromic) tall members and one individual with normal stature by whole exome sequencing; the tallest man had a height of 211 cm. Six heterozygous gene variants predicted as damaging were shared among the four genetically related tall individuals and not present in a family member with normal height. To gain insight into the putative role of these candidate genes in bone growth, we assessed the transcriptome of murine growth plate by microarray and RNA Seq. Two (Ift140, Nav2) of the six genes were well-expressed in the growth plate. Nav2 (p-value 1.91E-62) as well as Ift140 (p-value of 2.98E-06) showed significant downregulation of gene expression between the proliferative and hypertrophic zone, suggesting that these genes may be involved in the regulation of chondrocyte proliferation and/or hypertrophic differentiation. IFT140, NAV2 and SCAF11 have also significantly associated with height in GWAS studies. Pathway and network analysis indicated functional connections between IFT140, NAV2 and SCAF11 and previously associated (tall) stature genes. Knockout of the all-trans retinoic acid responsive gene, neuron navigator 2 NAV2, in Xenopus supports its functional role as a growth promotor. Collectively, our data expand the spectrum of genes with a putative role in tall stature phenotypes and, among other genes, highlight NAV2 as an interesting gene to this phenotype.
Palliative care as a digital working world (PALLADiUM) - a mixed-method research protocol
(2023) Grimminger, Sandra; Heckel, Maria; Markgraf, Moritz; Peuten, Sarah; Wöhl, Moritz; Gimpel, Henner; Klein, Carsten; Ostgathe, Christoph; Steigleder, Tobias; Schneider, Werner; Grimminger, Sandra; Palliativmedizinische Abteilung, Comprehensive Cancer Center CCC Erlangen-EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Heckel, Maria; Palliativmedizinische Abteilung, Comprehensive Cancer Center CCC Erlangen-EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Markgraf, Moritz; Project Group Business & Information Systems Engineering of the Fraunhofer FIT, Augsburg, Germany; Peuten, Sarah; Professorship for Sociology, University of Augsburg, Augsburg, Germany; Wöhl, Moritz; Project Group Business & Information Systems Engineering of the Fraunhofer FIT, Augsburg, Germany; Gimpel, Henner; Chair of Digital Management, University of Hohenheim, Stuttgart, Germany; Klein, Carsten; Palliativmedizinische Abteilung, Comprehensive Cancer Center CCC Erlangen-EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Ostgathe, Christoph; Palliativmedizinische Abteilung, Comprehensive Cancer Center CCC Erlangen-EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Steigleder, Tobias; Palliativmedizinische Abteilung, Comprehensive Cancer Center CCC Erlangen-EMN, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Schneider, Werner; Professorship for Sociology, University of Augsburg, Augsburg, Germany
Background:
In Palliative Care, actors from different professional backgrounds work together and exchange case-specific and expert knowledge and information. Since Palliative Care is traditionally distant from digitalization due to its holistically person-centered approach, there is a lack of suitable concepts enabling digitalization regarding multi-professional team processes. Yet, a digitalised information and collaboration environment geared to the requirements of palliative care and the needs of the members of the multi-professional team might facilitate communication and collaboration processes and improve information and knowledge flows. Taking this chance, the presented three-year project, PALLADiUM, aims to improve the effectiveness of Palliative Care teams by jointly sharing available inter-subjective knowledge and orientation-giving as well as action-guiding practical knowledge. Thus, PALLADiUM will explore the potentials and limitations of digitally supported communication and collaboration solutions.
Methods:
PALLADiUM follows an open and iterative mixed methods approach. First, ethnographic methods – participant observations, interviews, and focus groups – aim to explore knowledge and information flow in investigating Palliative Care units as well as the requirements and barriers to digitalization. Second, to extend this body, the analysis of the historical hospital data provides quantitative insights. Condensing all findings results in a to-be work system. Adhering to the work systems transformation method, a technical prototype including artificial intelligence components will enhance the collaborative teamwork in the Palliative Care unit.
Discussion:
PALLADiUM aims to deliver decisive new insights into the preconditions, processes, and success factors of the digitalization of a medical working environment as well as communication and collaboration processes in multi-professional teams.
Setting life cycle assessment (LCA) in a future-oriented context: the combination of qualitative scenarios and LCA in the agri-food sector
(2022) Voglhuber-Slavinsky, Ariane; Zicari, Alberto; Smetana, Sergiy; Moller, Björn; Dönitz, Ewa; Vranken, Liesbet; Zdravkovic, Milena; Aganovic, Kemal; Bahrs, Enno; Voglhuber-Slavinsky, Ariane; Institute of Farm Management, University of Hohenheim, Stuttgart, Germany; Zicari, Alberto; Division of Bioeconomics, Department of Earth and Environmental Sciences, KU Leuven, Leuven, Belgium; Smetana, Sergiy; DIL German Institute of Food Technologies e.V, Quakenbrück, Germany; Moller, Björn; Competence Center Foresight, Fraunhofer Institute for Systems and Innovation Research ISI, Karlsruhe, Germany; Dönitz, Ewa; Competence Center Foresight, Fraunhofer Institute for Systems and Innovation Research ISI, Karlsruhe, Germany; Vranken, Liesbet; Division of Bioeconomics, Department of Earth and Environmental Sciences, KU Leuven, Leuven, Belgium; Zdravkovic, Milena; DIL German Institute of Food Technologies e.V, Quakenbrück, Germany; Aganovic, Kemal; DIL German Institute of Food Technologies e.V, Quakenbrück, Germany; Bahrs, Enno; Institute of Farm Management, University of Hohenheim, Stuttgart, Germany
By combining qualitative scenarios and life cycle assessment (LCA), we place the latter in a larger context. This study outlines the importance of the integration of future perspectives into LCA, and also the significance of taking changes in the environment of technology into account, rather than just technological development itself. Accordingly, we focused on adapting the background system of an attributional LCA in the agri-food sector. The proposed technology was assumed not have evolved in the considered time horizon. In this context, the objectives of this paper were twofold: (i) to methodologically prove the applicability of integrating qualitative scenarios into LCA and (ii) to focus on changes in the background system, which is sometimes overlooked in the context of future-oriented LCA. This allowed to evaluate the future potential of different technologies, assessing their environmental impact under uncertain future developments. Methodologically, the qualitative information from scenarios was transformed into quantitative data, which was successively fed into the life cycle inventory (LCI) of the LCA approach. This point of integration into the second phase of LCA translates into future changes in the entire environment in which a technology is used. This means that qualitatively described scenario narratives need to be converted into value estimates in order to be incorporated into the LCA model. A key conclusion is that changes in the background of an LCA—the changing framework expressed through the inventory database—can be very important for the environmental impact of emerging technologies. This approach was applied to a food processing technology to produce apple juice. The proposed methodology enables technology developers to make their products future-proof and robust against socioeconomic development. In addition, the market perspective, if spelled out in the scenarios, can be integrated, leading to a more holistic picture of LCA with its environmental focus, while simultaneously empowering actors to make the right strategic decisions today, especially when considering the long investment cycles in the agri-food sector.
A low-tech approach to mobilize nutrients from organic residues to produce bioponic stock solutions
(2024) Heintze, Sebastian; Beckett, Marc; Kriem, Lukas Simon; Germer, Jörn; Asch, Folkard; Heintze, Sebastian; Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstr. 12, 70569 Stuttgart, Germany; (S.H.); (L.S.K.); Beckett, Marc; Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstr. 12, 70569 Stuttgart, Germany; (S.H.); (L.S.K.); Kriem, Lukas Simon; Fraunhofer Institute for Interfacial Engineering and Biotechnology, Nobelstr. 12, 70569 Stuttgart, Germany; (S.H.); (L.S.K.); Germer, Jörn; Hans-Ruthenberg Institute for Tropical Agricultural Sciences, University of Hohenheim, Garbenstr. 13, 70599 Stuttgart, Germany; (J.G.); (F.A.); Asch, Folkard; Hans-Ruthenberg Institute for Tropical Agricultural Sciences, University of Hohenheim, Garbenstr. 13, 70599 Stuttgart, Germany; (J.G.); (F.A.); Liu, Guodong
Organic residues, as a nutrient source suitable of producing solutions for hydroponic crop production, have the potential to reduce the dependence on mineral fertilizers. Especially in remote and resource-constrained regions, organic residues might be the only option to produce hydroponic nutrient solutions. However, nutrient solutions made from organic residues, called bioponic solutions, are usually unbalanced in their nutrient composition, which leads to deficiencies and poor plant growth. This study aimed to experimentally develop a low-tech approach to produce bioponic stock solutions rich in NO3−, P, and K, to create a balanced bioponic solution. The mixed bioponic solution contained 58 mg L−1 NH4+-N, 43 mg L−1 NO3−-N, 50 mg L−1 PO43−-P, and 246 mg L−1 K+. This approach resulted in satisfactory levels of P, K and micronutrients. The solution was tested pure and spiked with Ca(NO3)2 on lettuce in comparison with a mineral Hoagland nutrient solution. Neither the bioponic nor the spiked bioponic solution achieved comparable lettuce yields to the Hoagland solution. The poor growth of the plants in the bioponic solution was attributed to an unfavorable NH4+:NO3− ratio, high microorganism load, and elevated pH levels. However, the approach of preparing bioponic stock solutions could be promising for future research into the production of balanced bioponic nutrient solutions from organic residues.
Augmented reality marketing and consumer-brand relationships: how closeness drives brand love
(2024) Rauschnabel, Philipp A.; Hüttl‐Maack, Verena; Ahuvia, Aaron C.; Schein, Katrin E.
Marketers use augmented reality (AR) to place virtual brand-related information into a consumer's physical context. Grounded in the literature on AR, brand love, metaphor theory, and closeness as interpreted by the neural theory of language, the authors theorize that branded AR content can reduce the perceived physical, spatial distance between a consumer and a brand. This perceived closeness subsequently drives the closeness of the emotional relationship in the form of brand love. Two empirical studies validate this framework. Study 1 shows that using an AR app (vs. non-AR) increases the perceived physical closeness of the brand, which in turn drives brand love (i.e., relationship closeness). Study 2 replicates this finding in a pre-/post-use design. Here, high levels of local presence (i.e., the extent to which consumers perceive a brand as actually being present in their physical environment) drive perceived physical closeness, which leads to brand love. We also find that AR's power to generate brand love increases when the consumer is already familiar with the brand. We discuss managerial implications for AR marketing today and in a metaverse future in which AR content might be prevalent in consumers' everyday perceptions of the real world.