Newest publications
Does small firm dynamics matter for occupation diversity and job quality? Evidence from Brazil
(2024) Bueno, Alan; Cardoso, Ben Hur Francisco; Hartmann, Dominik; Ferraz, Diogo
Recent studies have explored the role of firm dynamics and the connection to job reallocation. However, limited attention has been devoted to the role of micro and small firms in this process, particularly about the quality of the jobs generated. Therefore, this article aims to measure the impact of micro and small firm dynamics on occupation diversification in Brazil, with specific emphasis on job quality. The study used data from 558 microregions within the Brazilian industrial sector between 2003 and 2015. Panel data were applied to three econometric models: Feasible Generalized Least Squares (FGLS), Driscoll–Kraay (DK) and Instrumental Variable (IV) models for robustness analysis, including Two-Stage Least Squares (2SLS), Limited Information Maximum Likelihood (LIML), and the Generalized Method of Moments with Continuously Updating Estimators (GMM-CUE). Our main finding reveals that the dynamics of micro and small firms positively impact occupation diversity in Brazil, leading to the creation of a wider range of job types. Furthermore, the frequency of change of firms from microenterprises to small businesses increases the occupation diversity in the Brazilian industrial sector. Our findings are significant in providing policy recommendations for developing countries to achieve a more diverse labor market .
Personalized, digitally designed 3D printed food towards the reshaping of food manufacturing and consumption
(2024) Derossi, Antonio; Spence, Charles; Corradini, Maria G.; Jekle, Mario; Fahmy, Ahmed Raouf; Caporizzi, Rossella; Devahastin, Sakamon; Moses, Jeyan Arthur; Le-Bail, Alain; Zhou, Weibiao; Zhang, Min; Bhandari, Bhesh; Severini, Carla
The emerging world of 3D food printing is reviewed. Its role in food manufacturing, including benefits and impacts, underemphasized gastrophysical aspects, and limitations are discussed. Foods can be digitally designed and physically prepared using the layer-by-layer deposition of food components, unleashing opportunities to deliver nutritionally personalized food and new food-human interactions. Existing bottlenecks, under-researched gastropsychophysical aspects, and the lack of harmonized standards hindering its use for mass production are mentioned.
Chorein regulates key osteoblast genes in UMR-106 cells
(2026) Feger, Martina; Tsapara, Anna; Hülße, Sina; Rausch, Steffen; Barholz, Michelle; Stournaras, Christos; Föller, Michael; Feger, Martina; Department of Physiology, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany; Tsapara, Anna; Department of Biochemistry, University of Crete Medical School, Heraklion, Greece; Hülße, Sina; Department of Physiology, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany; Rausch, Steffen; Department of Physiology, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany; Barholz, Michelle; Department of Physiology, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany; Stournaras, Christos; Department of Biochemistry, University of Crete Medical School, Heraklion, Greece; Föller, Michael; Department of Physiology, University of Hohenheim, Garbenstraße 30, 70599, Stuttgart, Germany
Chorein is an endoplasmic reticulum protein expressed in many cell types. Loss-of-function mutations of the gene encoding chorein ( VPS13A ) are the cause of chorea-acanthocytosis, a rare and severe neurodegenerative disease with chorea-like movements, loss of mental function, progressive muscle weakness and misshaped erythrocytes (acanthocytes). Chorein regulates diverse cellular functions including the cytoskeleton, apoptosis, Ca 2+ entry, or autophagy. Since its role in bone is enigmatic, we aimed to explore the function of chorein in osteoblasts. To this end, we generated UMR-106 osteoblast-like cells with stable chorein knockdown (KD) using a CRISPR/Cas9-based approach and compared them to cells undergoing CRISPR/Cas9 with a non-targeting sequence (NT). Gene expression was assessed by qPCR and protein by Western blotting and ELISA. Gene and protein expression of chorein and fibroblast growth factor 23 (FGF23), an osteoblast-derived hormonal regulator of phosphate metabolism, were decreased in KD compared to NT cells. Moreover, FGF23 regulator Phex was down- and Galnt3 was up-regulated in KD compared to NT cells. The expression of further genes regulating osteoblast and osteoclast differentiation was affected by chorein knockdown. Taken together, chorein is expressed in UMR-106 osteoblasts and modulates the expression of various genes affecting osteoblast and osteoclast differentiation and function.
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2/tNOX) is a potential prognostic marker in primary malignant melanoma and may serve as a therapeutic target
(2024) Böcker, Matti; Chatziioannou, Eftychia; Niessner, Heike; Hirn, Constanze; Busch, Christian; Ikenberg, Kristian; Kalbacher, Hubert; Handgretinger, Rupert; Sinnberg, Tobias; Cardinali, Giorgia; Flori, Enrica; Maresca, Vittoria
With an increasing incidence of malignant melanoma, new prognostic biomarkers for clinical decision making have become more important. In this study, we evaluated the role of ecto-NOX disulfide-thiol exchanger 2 (ENOX2/tNOX), a cancer- and growth-associated protein, in the prognosis and therapy of primary malignant melanoma. We conducted a tissue microarray analysis of immunohistochemical ENOX2 protein expression and The Cancer Genome Atlas (TCGA) ENOX2 RNA expression analysis, as well as viability assays and Western blots of melanoma cell lines treated with the ENOX2 inhibitor phenoxodiol (PXD) and BRAF inhibitor (BRAFi) vemurafenib. We discovered that high ENOX2 expression is associated with decreased overall (OS), disease-specific (DSS) and metastasis-free survival (MFS) in primary melanoma (PM) and a reduction in electronic tumor-infiltrating lymphocytes (eTILs). A gradual rise in ENOX2 expression was found with an increase in malignant potential from benign nevi (BNs) via PMs to melanoma metastases (MMs), as well as with an increasing tumor thickness and stage. These results highlight the important role of ENOX2 in cancer growth, progression and metastasis. The ENOX2 expression was not limited to malignant cell lines but could also be found in keratinocytes, fibroblasts and melanocytes. The viability of melanoma cell lines could be inhibited by PXD. A reduced induction of phospho-AKT under PXD could prevent the development of acquired BRAFi resistance. In conclusion, ENOX2 may serve as a potential prognostic marker and therapeutic target in malignant melanoma.
Sheltered by trees: long-term yield dynamics in temperate alley cropping agroforestry with changing water availability
(2025) Koch, Olef; Moore, Jennifer; Hörl, Jakob; Cormann, Michael; Gayler, Sebastian; Lewandowski, Iris; Marhan, Sven; Munz, Sebastian; Pflugfelder, Markus; Piepho, Hans-Peter; Schneider, Julia; von Cossel, Moritz; Weinand, Tanja; Winkler, Bastian; Schweiger, Andreas H.
As warm season droughts increase in frequency due to climate change, causing severe yield losses especially among cereal crops, European agriculture is in dire need of adaptation. While agroforestry is widely regarded as a key adaptation measure, little is known on how yield performance is influenced by changing water availability in temperate regions. Therefore, we assessed the yield dynamics of five winter crops (winter wheat, triticale, winter barley, winter pea, and rapeseed) during seven growing seasons (2012 to 2023) in a well-established (since 2007) alley cropping agroforestry trial site in Southwestern Germany. The trial integrated three different agroforestry practices in a randomized block design: (i) willow short-rotation coppice, (ii) walnut trees for nut production, and (iii) diverse hedgerows. The relationship between crop yield and climatic water balance was analyzed using a linear mixed-model. In this unique long-term comparison, we demonstrate that individual alley cropping practices exhibited distinct yield patterns with increased distance to tree rows. In contrast to the willow short rotation coppice, walnut and hedgerows did not evoke significant winter crop yield declines at proximity. While in the walnut plots yields did not significantly vary with distance to tree rows, yields adjacent to hedge rows declined significantly towards the alley center. Moreover, tree rows contributed to stable crop yields under fluctuating water availability in their proximity and up to the alley center on their leeward side while yields significantly varied with changing climatic water balance on the windward side. Our results underline the potential of agroforestry to sustain yields in the face of increasingly variable water availability, further substantiating the contribution of alley cropping agroforestry for farming systems’ resilience to increasingly variable weather conditions. They moreover contribute to planning and policy support for advancing agroforestry as a climate smart solution in temperate regions.