Browsing by Subject "Cardiopulmonary fitness"

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    Precursor fractions of neurotensin and enkephalin might point to molecular mechanisms of cancer risk modulation during a lifestyle-intervention in germline BRCA1/2 gene mutation carriers
    (2021) Grill, Sabine; Yahiaoui-Doktor, Maryam; Basrai, Maryam; Struck, Joachim; Schulte, Janin; Berling-Ernst, Anika; Engel, Christoph; Ullrich, Mirjam; Lammert, Jacqueline; Bischoff, Stephan C.; Schmidt, Thorsten; Niederberger, Uwe; Chronas, Dimitrios; Rhiem, Kerstin; Schmutzler, Rita; Halle, Martin; Kiechle, Marion
    Background: Germline BRCA1/2 mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)—involved in tumorigenesis and obesity-related diseases—are of interest. We wanted to know whether these biomarkers differ between gBMC and women from the general population and what effect a 1-year lifestyle-intervention has in gBMC. Methods: The stable precursor fragments pro-NT and pro-ENK were measured at study entry (SE), after 3 and 12 months for 68 women from LIBRE-1 (a controlled lifestyle-intervention feasibility trial for gBMC involving structured endurance training and the Mediterranean Diet). The SE values were compared with a cohort of the general population including female subjects with and without previous cancer disease, non-suggestive for hereditary breast and ovarian cancer (OMA-reference). For LIBRE-1, we analysed the association between the intervention-related change in the two biomarkers and certain lifestyle factors. Results: At SE, gBMC had a higher median pro-NT than OMA-reference (in the subgroups with previous cancer 117 vs. 91 pmol/L, p = 0.002). Non-diseased gBMC had lower median pro-ENK levels when compared to the non-diseased reference group. VO2peak and pro-NT 1-year change in LIBRE-1 were inversely correlated (r = − 0.435; CI − 0.653 to − 0.151; p = 0.004). Pro-ENK correlated positively with VO2peak at SE (r = 0.323; CI 0.061–0.544; p = 0.017). Regression analyses showed an inverse association of 1-year changes for pro-NT and Omega-6/Omega-3 (Estimate: − 37.9, p = 0.097/0.080) in multivariate analysis. Conclusion: Our results give first indications for lifestyle-related modification particularly of pro-NT in gBMC.
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    Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)
    (2022) Berling-Ernst, Anika; Yahiaoui-Doktor, Maryam; Kiechle, Marion; Engel, Christoph; Lammert, Jacqueline; Grill, Sabine; Dukatz, R.; Rhiem, Kerstin; Baumann, F. T.; Bischoff, Stephan C.; Erickson, N.; Schmidt, Thorsten; Niederberger, Uwe; Siniatchkin, M.; Halle, Martin; Berling-Ernst, A.; Department of Prevention and Sports Medicine, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Yahiaoui-Doktor, M.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany; Kiechle, M.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Engel, C.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany; Lammert, J.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Grill, S.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Dukatz, R.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Rhiem, K.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany; Baumann, F. T.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany; Bischoff, S. C.; Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany; Erickson, N.; Comprehensive Cancer Center Ludwig Maximillian University (CCC LMU), University of Munich Clinic, Munich, Germany; Schmidt, T.; University Cancer Center Schleswig-Holstein (UCCSH), Kiel, Germany; Niederberger, U.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany; Siniatchkin, M.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany; Halle, M.; DZHK (German Centre for Cardiovascular Research), Munich, Germany
    Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO2peak) in BRCA1/2 mutation carriers whose risk of developing BC is high. We used cross-sectional data from 68 BRCA1/2 germline mutation carrying women participating in the randomized, prospective, controlled clinical study LIBRE-1. Assessments included cardiopulmonary exercise testing, medical and lifestyle history plus socioeconomic status. Additionally, the participants completed a psychological questionnaire regarding their attitude, subjective norms, perceived behavior control and intention towards PA. A multivariate logistic regression model was used to identify predictors for participants reaching their age- and sex-adjusted VO2peak reference values. 22 participants (median age: 40 years, interquartile range (IQR) 33–46) were cancer-unaffected and 46 cancer-affected (median age: 44 years, IQR 35–50). The strongest predictor for reaching the reference VO2peak value was attitude towards PA (Odds Ratio 3.0; 95% Confidence Interval 1.3–8.4; p = 0.021). None of the other predictors showed a significant association. A positive attitude towards PA seems to be associated with VO2peak, which should be considered in developing therapeutic and preventive strategies.Trial registrations: NCT02087592; DRKS00005736.