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Article
2024
Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)
Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)
Abstract (English)
Background: Chronic alcohol intake is associated with alterations of choline metabolism in various tissues. Here, we assessed if an oral choline supplementation attenuated the development of alcohol-related liver disease (ALD) in mice.
Methods: Female C57BL/6 J mice (n = 8/group) were either pair-fed a liquid control diet, or a Lieber DeCarli liquid diet (5% ethanol) ± 2.7 g choline/kg diet for 29 days. Liver damage, markers of intestinal permeability and intestinal microbiota composition were determined. Moreover, the effects of choline on ethanol-induced intestinal permeability were assessed in an ex vivo model.
Results: ALD development as determined by liver histology and assessing markers of inflammation (e.g., nitric oxide, interleukin 6 and 4-hydroxynonenal protein adducts) was attenuated by the supplementation of choline. Intestinal permeability in small intestine being significantly higher in ethanol-fed mice was at the level of controls in ethanol-fed mice receiving choline. In contrast, no effects of the choline supplementation were found on intestinal microbiota composition. Choline also significantly attenuated the ethanol-induced intestinal barrier dysfunction in small intestinal tissue ex vivo, an effect almost entirely abolished by the choline oxidase inhibitor dimbunol.
Conclusion: Our results suggest that an oral choline supplementation attenuates the development of ALD in mice and is related to a protection from intestinal barrier dysfunction.
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Molecular medicine, 30 (2024), 1, 181,
https://doi.org/10.1186/s10020-024-00950-4.
ISSN: 1528-3658
London : BioMed Central
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Sánchez, V., Baumann, A., Kromm, F., Yergaliyev, T., Brandt, A., Scholda, J., Kopp, F., Camarinha-Silva, A., & Bergheim, I. (2024). Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD). Molecular medicine, 30(1). https://doi.org/10.1186/s10020-024-00950-4
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610 Medicine and health
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Sustainable Development Goals
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@article{Sánchez2024,
doi = {10.1186/s10020-024-00950-4},
author = {Sánchez, Victor and Baumann, Anja and Kromm, Franziska et al.},
title = {Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)},
journal = {Molecular medicine},
year = {2024},
volume = {30},
number = {1},
}