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It is crucial for the growth and development of an organism whether ammonium is transported across its membranes in a form of NH4+ or NH3. The transport of both molecules follows different pH-dependent gradients across membranes and transport of both substrates differentially affects the internal and external pH. As a consequence, they directly influence the physiology and organism development. CaMep2 from Candida albicans shows a dual transceptor function in ammonium transport and sensing. CaMep2 senses low ammonium availability and induces filamentous growth. CaMep1, by contrast, is only active in transport, but not involved in ammonium signaling. Here, both proteins were heterologously expressed in Xenopus laevis oocytes. This study identified electrogenic NH4+ transport by CaMep1 and electroneutral NH3 transport by CaMep2, which might be a prerequisite for the induction of pseudohyphal growth.
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Mycological progress, 19 (2020), 10, 1143-1149.
https://doi.org/10.1007/s11557-020-01625-0.
ISSN: 1861-8952
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Neuhäuser, B. (2020). Distinct transport mechanism in Candida albicans methylammonium permeases. Mycological progress, 19(10). https://doi.org/10.1007/s11557-020-01625-0
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@article{Neuhäuser2020,
url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16293},
doi = {10.1007/s11557-020-01625-0},
author = {Neuhäuser, B.},
title = {Distinct transport mechanism in Candida albicans methylammonium permeases},
journal = {Mycological progress},
year = {2020},
volume = {19},
number = {10},
pages = {1143--1149},
}